4 evaluation of the impact of dose intense cytotoxic chemotherapy regimens
Báo cáo khoa học: " The TGF-β1 dynamics during radiation therapy and its correlation to symptomatic radiation pneumonitis in lung cancer patients" potx
Ngày tải lên :
09/08/2014, 10:20
... Figure RP pattern of the changes of the Thegroup and the non-RP group mean TGF-β1 level in the The pattern of the changes of the mean TGF-β1 level in the RP group and the non-RP group The TGF-β1 level ... of RT The solid line shows the mean level of TGF-β1 in the RP group and the dashed line shows the mean level of TGF-β1 in the non-RP group The data are presented as mean ± standard error of the ... [8,9,12-18] A study of the dynamics of the serum cytokines during the early course of the treatment would be useful for predicting the risk of pulmonary injury and for the early intervention of pneumonitis...
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Báo cáo khoa học: "Improved survival following surgery and radiation therapy for olfactory neuroblastoma: analysis of the SEER database" pdf
Ngày tải lên :
09/08/2014, 09:20
... model The Role of Chemotherapy The SEER database did not include information for those treated with chemotherapy, however recent reports of outcomes for ONB patients have included chemotherapy ... description of this cohort can be found in Table There was a unimodal distribution of ages with most cases between the ages of 40 and 70 years old (mean age was 53 years, SD of 18) The majority of cases ... or radiotherapy The distribution of treatment methods and outcomes among the 511 cases is shown in Table There was a statistically significant difference in the overall survival between these four...
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Báo cáo khoa học: "Postmastectomy irradiation in breast in breast cancer patients with T1-2 and 1-3 positive axillary lymph nodes: Is there a role for radiation therapy" ppsx
Ngày tải lên :
09/08/2014, 09:20
... any relapse in the area of surgery between the sternum and the anterior axillary line, and below the inferior clavicular fossa and above the seventh rib Any relapse involving the axillary lymph ... significantly by adjuvant chemotherapy and/or hormonotherapy alone [7-10] All patients in the RT group received systemic adjuvant therapy It was state by Truong et al., that the percentage of positive lymph ... Another debate about PMRT is about the rational of peripheral lymphatic portal addition to the chest wall irradiation In our series there were peripheral lymphatic recurrence out of LRR in the...
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Frontiers of Radiation Therapy and Oncology Vol. 34 doc
Ngày tải lên :
28/03/2014, 11:20
... disease) The dose delivered to the tumor (and the pathological type of the tumor) is the key point for local Significance of Local Tumor Control control The history of one century of radiotherapy ... response of normal tissue stem cells to irradiation, studying the dose dependence of their clonogenic survival Typical examples are the stem cells of the bone marrow [3], of the gut [4] or of the ... of the patient’s contour, target volume, organs at risk and the 3D isodose distribution of the 80% isodose Inverse Planning of Conformal Therapy A completely new approach to the solution of the...
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Báo cáo khoa học: "SemiIntensity-modulated radiation therapy (IMRT) vs. 3D conformal radiotherapy (3DCRT) in locally advanced rectal cancer (LARC): dosimetric comparison and clinical implications" pptx
Ngày tải lên :
09/08/2014, 08:22
... border of the sacrum The anterior border of the lateral fields usually covered at least the posterior border of the vagina or the prostate, the anterior extent of the primary rectal tumor, and the ... when the PTV95 was ≥ 45 Gy, the dose received by 5% of the SB (SB D ) was ≤ 50 Gy, the PTV (minimal dose to the PTV) was ≥ 35 Gy, and maximal SB dose (SBmax) was 55 Gy Dose constraints for the ... begining of IMRT, there is no data available in the context of LARC Taking into account the benefits of IMRT and published data of the incidence of second malignancies and its relation with dose...
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Báo cáo khoa học: "Use of kilovoltage X-ray volume imaging in patient dose calculation for head-and-neck and partial brain radiation therapy" pptx
Ngày tải lên :
09/08/2014, 08:23
... has the data of 94.5% Table shows the dose to the tumor and some normal structures of the three patients in the planning CT data sets and the first CBCT data sets The differences of the dose ... distributions on the transverse planes of the three patients The left images represent dose distributions based on the kVCBCT and the right had images represent the dose on kV-CT images There is no ... error of less than 1.5% The stability of kV-CBCT number and electron density indicates acceptable overall performance of the kV-CBCT system The kV-CBCT images of the uniformity section of the phantom...
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Báo cáo khoa học: "Comparison of coplanar and noncoplanar intensity-modulated radiation therapy and helical tomotherapy for hepatocellular carcinom" pot
Ngày tải lên :
09/08/2014, 08:23
... indwelling catheters or catheter-related sepsis, which hinder arterial infusion chemotherapy While the role of radiotherapy was limited in the past because of poor tolerance of the whole liver ... VTV is the treated volume enclosed by the prescriptiond isodose surface, and TVPV is the portion of the PTV within the prescribed isodose volume The CI approximates unity means lesser dose to ... suitable for other treatment modalities [17,18,20] Cheng et al [25] reported that IMRT offers the better potential of increasing the dose conformality to the tumor and reducing the dose to the sensitive...
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Báo cáo khoa học: "An investigation of intensity-modulated radiation therapy versus conventional two-dimensional and 3D-conformal radiation therapy for early stage larynx cancer" ppt
Ngày tải lên :
09/08/2014, 09:20
... relationship between the coverage of the PTV and the level of expansion was dependent on the spatial relationship between the expanded borders of the PTV and the predetermined boundaries of the clinical ... posterior edge, at the discretion of the authors, was chosen as the prescription isodose The wedge angle chosen for the plan was the one which concentrated a dose of 102105% anteriorly Only the isocenter ... course of 38 days This dose schedule corresponds to a nominal standard dose, which is used to compare the effect of different dose regimens, of 1905 ret, the unit for nominal standard dose 2D...
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Báo cáo khoa học: "Plan comparison of volumetric-modulated arc therapy (RapidArc) and conventional intensitymodulated radiation therapy (IMRT) in anal canal cancer" doc
Ngày tải lên :
09/08/2014, 09:20
... minimum doses Mean dose (D mean) was also reported The degree of conformity of the plans was defined as the ratio between the volume receiving at least 95% of the prescribed dose and the volume of the ... Once the treatment planning was completed, the plan was normalized to cover 99% of the PTV2 with ≥ 95% of the prescribed dose We also checked that 95% of the PTV1 received 95% of the prescribed dose ... For RA2, the first arc was similar to the one defined in the RA1 process except for the rotation of the collimator, which was 360-X for the second arc (X corresponded to the rotation of the collimator...
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Báo cáo khoa học: "Whole abdomen radiation therapy in ovarian cancers: a comparison between fixed beam and volumetric arc based intensity modulation" ppt
Ngày tải lên :
09/08/2014, 09:20
... 107% of the prescribed dose) were reported The homogeneity of the dose distribution, was measured by D5%-D95% and expressed as U5-95% = D5%D95%/Dmean The lower this value, the better is the dose ... the conformity of the high dose levels For OARs, the analysis included the mean dose, the maximum dose expressed as D2% and a set of VXGy (OAR volume receiving at least x Gy) depending upon the ... Healthy Tissue (defined as the entire body volume included in the CT scan minus the PTVs), the integral dose, “DoseInt” was defined as the integral of the absorbed dose extended to over all voxels...
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Báo cáo khoa học: "Comparison of conformal and intensity modulated radiation therapy techniques for treatment of pelvic tumors. Analysis of acute toxicity" pdf
Ngày tải lên :
09/08/2014, 09:20
... that the low number of events could have limited the statistical power of this analysis Another advantage of IMRT is the possibility to deliver a different level of daily dose to the distinct target ... Results of these two trials will contribute to assess the benefits and risks of IMRT in patients with gynecologic tumors The most important result from our series was the lower incidence of medication ... malabsorption of vitamins, lactose, and bile acids [4] Another important finding was the higher absence of GI symptoms (grade 0) in IMRT group (43.1% versus 8.7%; p < 0.001) The possibility of offering...
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Báo cáo khoa học: " Stereotactic body radiation therapy for melanoma and renal cell carcinoma: impact of single fraction equivalent dose on local control" ppt
Ngày tải lên :
09/08/2014, 09:20
... superior-inferior direction The dose was prescribed to cover at least 95% of the PTV, normalized to the isodose line representing 60-80% of the maximum dose inside the PTV The majority of plans were generated ... prescription dose on the order of 48-49 Gy or higher It should be appreciated that this dose estimate represents the dose covering the periphery of the PTV and that substantial dose hotspots ... describes the slope of the curve Doses to individual lesions were grouped into tertile bins, and the x-axis value was the mean dose given in that bin, expressed as either BED or SFED, while the y-axis...
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Báo cáo khoa học: "Intensity modulated radiation therapy (IMRT): differences in target volumes and improvement in clinically relevant doses to small bowel in rectal carcinoma" pps
Ngày tải lên :
09/08/2014, 09:20
... consisted of the bilateral femoral heads and necks to the level of the lesser trochanter The pelvic bones contours were defined as the exterior of the bony table from top of the iliac crests to the ... calculated for the 3DCRT and IMRT plans HI was expressed as (D5% - D95%) / prescription dose CI was expressed as the ratio of the absolute volume receiving the prescription dose to the volume of the target, ... in the recently completed phase II protocol, RTOG 0822 [18] Therefore, the aim of our study is to further elucidate the potential role for IMRT in the management of locally-advanced carcinoma of...
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Báo cáo khoa học: "Reirradiation of head and neck cancer focusing on hypofractionated stereotactic body radiation therapy" pdf
Ngày tải lên :
09/08/2014, 09:21
... frequently offered adjuvant reirradiation alone or with chemotherapy The likelihood of cure is impacted by the interval between the initial course of radiotherapy and reirradiation depending on, whether ... sculpt the dose around critical structures and thus increase the total dose, will outweigh the theoretical concerns of an increased volume of tissue receiving low -dose radiation Page of 10 However, ... 2-week cycles of days of chemoradiotherapy, followed by a 9-day break Radiotherapy was administered either daily or twice daily (bid), with a mean total dose of 64.8 Gy The majority of patients...
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Báo cáo khoa học: "Effects of radiation therapy on tissue and serum concentrations of tumour associated trypsin inhibitor and their prognostic significance in rectal cancer patients" doc
Ngày tải lên :
09/08/2014, 09:21
... participated in the conception of the study, BN assisted with the TMA construction and revision of the manuscript, UHS participated in revision of the manuscript, BJ participated in the conception ... drafted the manuscript CS participated in the collection of tissue samples, data and revised the manuscript KH performed the serum analyses and revised the manuscript IP assisted in the collection of ... As we are not aware of any previous studies describing the effects of RT on the tumour-specific expression of TATI or its serum concentrations in any cancer form, the aim of the present study was...
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Báo cáo khoa học: "Acute and late toxicity in prostate cancer patients treated by dose escalated intensity modulated radiation therapy and organ tracking" pps
Ngày tải lên :
09/08/2014, 09:22
... The dose was applied by the dynamic MLC technique using an 80 leaf-MLC The 80 Gy were prescribed to the median of the PTV More than 99% of the PTV volume was included in the 95% isodose and the ... procedure, the patient was treated with the multi-field IMRT plan Optimization of the IMRT plan included a dose limit within the central periurethral area of 99% of the prescribed dose The duration of ... third of the SV was included to the clinical target volume (CTV) electively If invasion of the base of the SV was seen in the MRI (cT3b), the whole SV were electively included to the CTV The planning...
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Báo cáo khoa học: "Target splitting in radiation therapy for lung cancer: further developments and exemplary treatment plans" pps
Ngày tải lên :
09/08/2014, 10:20
... 300°) Two of these fields (120°, 300°) meet also the PTV of the nodes, the missing dose to the nodes is added by two fields, which not interfere with the primary tumor After 63,0 Gy the primary ... volume, the primary tumor is treated by three, partially wedged fields (290°, 345°, 50°); only one of these fields (345°) meets also the PTV of the nodes, situated only in the upper cm of the caudal ... the level where the lower edge of the pulmonary trunk crosses the median to the apex of the heart Esophagus and spinal cord are contoured in their entire thoracic length Page of 10 (page number...
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Báo cáo khoa học: " Comparison of CT and integrated PET-CT based radiation therapy planning in patients with malignant pleural mesothelioma" pot
Ngày tải lên :
09/08/2014, 10:20
... in the lesion and then set the upper window level to this maximum value and set the lower window level to 42% of the maximum level Statistical Analysis On the basis of the literature, we hypothesized ... injection The subsequent PET scan was acquired from the base of the skull to the inferior border of the pelvis as in the CT scan, using multiple-bed position Attenuation was corrected by using the ... ensure that they were below 150 mmol/L The patients were scanned on a flat-panel carbon fiber composite table insert An enhanced CT scan from the base of the skull to the inferior border of the pelvis...
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Báo cáo khoa học: " Whole brain radiation therapy in management of brain metastasis: results and prognostic factors" ppsx
Ngày tải lên :
09/08/2014, 10:21
... the time of analysis were censored with the date of last follow-up The endpoint of the study was overall survival Survival was calculated from the first day of radiotherapy using the method of ... Standard treatment regimens include all of the dose ranges evaluated in the early RTOG studies, and is dependent upon issues such as the severity of CNS symptoms, the extent of systemic disease, ... fractions of Gray (Gy), five days per week to a planned total dose of 40 Gy (n = 102) and hypofractionation with daily fractions of Gy, five days per wk to a planned total dose of 30 Gy (n = 134) The...
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